Useful nutritional supplements for arthrosis
REVIT ARTHRO is a unique combination of high-dose hyaluronic acid and chondroitin sulfate in an innovative liquid complex for efficient absorption and maximum bioavailability.
According to scientific studies, the body's own production of hyaluronic acid decreases with age, so supplementing with hyaluronic acid can effectively support joint function. Research has shown that in humans, hyaluronic acid production is already reduced by 50% by the age of 40 compared to the original production. According to researchers, by the age of 60, only 10% of the original hyaluronic acid production is achieved. ² .
Hyaluronic acid and chondroitin are essential components of the inner joint space and can enable smooth functioning in the joints. These two substances produced by the body can support the natural dampening properties of the articular cartilage and the lubricating function of the viscous synovial fluid in the joint space. ³'⁴
In scientific studies, the intake of hyaluronic acid and chondroitin was able to promote the physiological function and regenerative capacity of the joints ⁵. Some studies have also indicated that the two active ingredients can complement each other optimally when combined ⁶'⁷. In addition to a supply of specific cartilage nutrients , the joints can also benefit from regular and gentle exercise.
Our precious hyaluronic acid has been formulated with an optimal molecular mass and structure to allow absorption through the digestive tract and release into the bloodstream. Hyaluronic acid taken orally can be distributed throughout the body and to all joints ⁸, whereas an injection of hyaluronic acid only reaches the injected joint.
New research suggests that hyaluronic acid, at optimal molecular size and concentration, can induce the growth and regeneration of cartilage cells in the joint via specific receptors ⁹'¹⁰'¹¹.
The high dose of vitamin E is a powerful antioxidant and can help protect cells from oxidative stress. Scientific studies have shown that vitamin E can have a positive effect on joint function by reducing oxidative stress and inflammation ¹².
Studies and health claims
² Saranraj, P. and M. Naidu (2013). "Hyaluronic acid production and its applications—a review." Int J Pharm Biol Arch 4(5): 853-859.
³ Tashiro, T., et al. (2012). "Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period." The Scientific World Journal 2012: 167928.
⁴ Martel-Pelletier, J., et al. (2010). "Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review." Osteoarthritis Cartilage 18 Suppl 1: S7-11.
⁵ Wang, S.-J., et al. (2021). "The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial." Medicine 100(5): e24252-e24252.
⁶ Nelson, FR, et al. (2015). "The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses." Rheumatology International 35(1): 43-52.
⁷ Oliviero, F., et al. (2020). "Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study." Reumatismo 72(3): 125-130.
⁸ Gupta, RC, et al. (2019). "Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory." Frontiers in Veterinary Science 6.
⁹ Wu, S.-C., et al. (2018). "Hyaluronan size alters chondrogenesis of adipose-derived stem cells via the CD44/ERK/SOX-9 pathway." Acta Biomaterialia 66: 224-237.
¹⁰ Wu, S.-C., et al. (2013). "Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose-derived stem cells." Journal of Applied Physiology 114(11): 1610-1618.
¹¹ Akmal, M., et al. (2005). "The effects of hyaluronic acid on articular chondrocytes." The Journal of Bone and Joint Surgery. British volume 87-B(8): 1143-1149.
¹² Chin, K.-Y. and S. Ima-Nirvana (2018). "The Role of Vitamin E in Preventing and Treating Osteoarthritis – A Review of the Current Evidence." Frontiers in Pharmacology 9: 946.
Important instructions:
The food supplement is not a substitute for a varied and balanced diet and a healthy lifestyle. The recommended intake must not be exceeded. Once opened, store in a cool place and use according to the recommended intake. Keep out of the reach of children. Use under medical supervision.