REVIT NIGHT - Sleep aid

Promotes restful sleep and supports intensive regeneration by activating autophagy.

Our REVIT NIGHT is different from conventional "sleep sprays" available in many pharmacies. The careful combination of natural ingredients and plant extracts in REVIT Night aims to support relaxed sleep and promote the body's natural regeneration processes, commonly known as autophagy .

Active ingredients:

The body's own hormone melatonin regulates the sleep-wake rhythm and is therefore called the sleep hormone. It is produced in the pineal gland in the diencephalon during darkness. Taking melatonin about 30 minutes before going to bed helps to shorten the time it takes to fall asleep ¹. Melatonin also helps to alleviate the subjective feeling of jet lag ². In combination with our high-dose valerian root extract, it has a calming effect and promotes sleep - without synthetic active ingredients and without the effect of habituation or a "hangover" the next day.

Current studies indicate that intense lighting in living rooms and the bright light from smartphone, tablet or computer displays can impair the body's production of melatonin. Problems falling asleep can occur if the melatonin concentration in the body is too low when going to bed. Surveys suggest that around one in three people in Germany suffer from sleep problems (TK - Sleep Study).

Our wheat germ extract contributes to cell regeneration during sleep. The spermidine it contains is considered a natural trigger for autophagy, a process within the cells that initiates the body's own recycling program ³. This process encloses deposits in the cells, such as byproducts and breakdown products of natural metabolism or faulty proteins, in small vesicles in order to break them down into their components. These components can be recycled by the cell or expelled from the cell. In this way, autophagy contributes to the removal of harmful deposits in the cells and supports the cleaning of the cells.

Spermidine is a substance produced naturally in the body that may no longer be produced sufficiently as we age, which can lead to a decrease in autophagy. ⁴'⁵ Studies suggest that deposits in the cells may be linked to neurodegenerative diseases such as dementia or Alzheimer's disease ⁶'⁷. The performance of heart muscle cells (myocardial cells) can also be impaired by reduced autophagy, which can lead to cardiovascular problems such as high blood pressure. ⁸'⁹

Autophagy may also play a role in preventing cancer by digesting dysfunctional organelles and breaking down proteins into their component parts, thereby helping abnormal cells die.¹⁰

L-ornithine is an amino acid that is found primarily in the urinary cycle and helps neutralize excess nitrogen. The importance of L-ornithine therefore lies in the breakdown of waste products.¹¹

Our green tea extract contains high levels of L-theanine , an amino acid that may help improve sleep quality by promoting the release of calming and stress-reducing neurotransmitters. Restlessness and stress are often considered the main reasons for difficulty falling asleep. Some research suggests that taking L-theanine can lead to a significant increase in alpha wave activity in the brain and a reduced heart rate. An increased level of alpha waves in the brain is associated with light relaxation, or relaxed alertness with eyes closed¹². Additionally, L-theanine has been found to be able to neutralize the stimulating effects of caffeine .

The vitamin B6 it contains helps to support sufficient sleep duration . Vitamin B6 is involved in the conversion of stored proteins and carbohydrates into glucose and thus supports glucose metabolism¹³ and energy metabolism¹⁴. The glucose formed through this conversion plays a role in maintaining normal blood sugar levels between meals and during the night. A lack of vitamin B6 in the body could lead to low blood sugar levels at night, which could potentially lead to frequent or early awakenings. In such cases, the stimulating hormone adrenaline can be released in increased amounts and promote awakening.

In addition, the vitamin B6 it contains supports the body's own melatonin production throughout the night. The body's own melatonin helps to ensure a healthy sleep duration and promotes the melatonin-induced deep sleep phase . Some studies have also indicated that a lack of vitamin B6 could be associated with symptoms such as muscle twitches, cramps, anxiety and abnormal brain waves during sleep, in addition to possible sleep disorders.

The addition of zinc helps protect cells from oxidative stress ¹⁵ and plays an important role in cell division ¹⁶ and the synthesis of DNA ¹⁷. Zinc is also important for various processes in metabolism ¹⁸ and the immune system.¹⁹

Studies and health claims

¹ Health Claim: Melatonin helps to shorten the time it takes to fall asleep

² Health Claim: Melatonin helps alleviate the subjective sensation of jet lag

³ Fîlfan, M., et al. (2017). "Autophagy in aging and disease." Rom J Morphol Embryol 58(1): 27-31.

⁴ Matsumoto, M. (2015). Polyamines and longevity in mammals. Polyamines, Springer: 257-266.

⁵ Morselli, E., et al. (2011). "Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome." The Journal of cell biology 192: 615-629.

⁶ Yang, X., et al. (2020). "Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans." Aging 12(17): 16852.

⁷ Pekar, T., et al. (2021). "The positive effect of spermidine in older adults suffering from dementia." Wiener klinische Wochenschrift 133(9): 484-491.

⁸ Eisenberg, T., et al. (2016). "Cardioprotection and lifespan extension by the natural polyamine spermidine." Nature Medicine 22(12): 1428-1438.

⁹ Abdellatif, M., et al. (2018). "Autophagy in Cardiovascular Aging." Circulation Research 123(7): 803-824.

¹⁰ Madeo, F., et al. (2019). "Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?" Autophagy 15(1): 165-168.

¹¹ Miyake, M., et al. (2014). "Randomized controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers." Nutrition Journal 13(1): 53.

¹² Bulman, A., et al. (2023). "The Effects of L-Theanine Supplementation on Quality of Sleep: A Systematic Review." Proceedings 91(1): 32.

¹³ Health Claim: Vitamin B6 contributes to normal protein and glycogen metabolism

¹⁴ Health Claim: Vitamin B6 contributes to normal energy metabolism

¹⁵ Health Claim: Zinc helps protect cells from oxidative stress

¹⁶ Health Claim: Zinc has a function in cell division

¹⁷ Health Claim: Zinc contributes to normal DNA synthesis

¹⁸ Health Claim: Zinc contributes to normal macronutrient metabolism

¹⁹ Health Claim: Zinc contributes to the normal function of the immune system